PFE options flow: unusual options activity in Pfizer Inc.
Updated 28 September 2026, 09:54 ET
Over the last week the tape recorded 49 unusual options prints in Pfizer Inc. (PFE), $4.6M of tracked premium, leaning bearish. Bullish premium was $1.9M against $2.4M bearish; $2.6M went into calls and $2.0M into puts, a put call ratio of 0.75. The largest print was $736K of PFE 21 Jan 2028 $27 calls on 25 September 2026, executed at bid. The last session with prints, 28 September 2026, added 2 prints and $93K of premium. PFE closed at $28.67 on 25 September 2026, up 0.9%.
This week's unusual flow
Prints from 21 September 2026 to 28 September 2026, 6 sessions. Delayed tier: every print is shown twenty minutes after it executed, and the page is rebuilt after each session.
Net premium is bullish minus bearish premium. The put call ratio is put premium divided by call premium, weighted by money rather than by contract count. Sweeps is the share of prints executed across several exchanges at once. Read the guide: Reading the Pulse.
Largest prints of the week
| Date | Contract | Type | Size | Open int. | Premium | Execution | Sentiment | Tier |
|---|---|---|---|---|---|---|---|---|
| 25 Sep 2026 | PFE 21 Jan 2028 $27 calls | Trade | 2,000 | 21,366 | $736K | At bid | Bearish | Notable |
| 21 Sep 2026 | PFE 20 Nov 2026 $25 puts | Trade | 20,000 | 5,462 | $540K | At bid | Bullish | Notable |
| 21 Sep 2026 | PFE 15 Jan 2027 $27 puts | Sweep | 4,409 | 29,823 | $534K | At ask | Bearish | High conviction |
| 22 Sep 2026 | PFE 16 Oct 2026 $28 calls | Sweep | 7,002 | 27,255 | $350K | At bid | Bearish | Notable |
| 25 Sep 2026 | PFE 19 Jan 2029 $25 calls | Trade | 394 | 538 | $225K | At ask | Bullish | Notable |
| 21 Sep 2026 | PFE 15 Jan 2027 $27 puts | Sweep | 1,001 | 29,823 | $116K | At ask | Bearish | Notable |
| 21 Sep 2026 | PFE 18 Dec 2026 $45 puts | Trade | 60 | 1 | $105K | At bid | Bullish | Notable |
| 24 Sep 2026 | PFE 20 Nov 2026 $28 calls | Sweep | 794 | 10,660 | $103K | At bid | Bearish | Notable |
| 23 Sep 2026 | PFE 18 Dec 2026 $42 puts | Sweep | 64 | 0 | $91K | At midpoint | Neutral | Notable |
| 23 Sep 2026 | PFE 20 Nov 2026 $30 calls | Sweep | 2,659 | 11,852 | $90K | At ask | Bullish | Notable |
| 22 Sep 2026 | PFE 16 Oct 2026 $28 calls | Sweep | 1,696 | 27,255 | $86K | At ask | Bullish | Notable |
| 24 Sep 2026 | PFE 18 Dec 2026 $29 calls | Sweep | 667 | 22,439 | $75K | At ask | Bullish | Notable |
Size above open interest means the trade opened a position larger than everything that existed in the contract the night before. Above ask and below bid are the most aggressive executions. Read the guide: Size versus open interest.
Where the money is aimed
| Expiry | Prints | Premium | Calls share | Net premium |
|---|---|---|---|---|
| 20 Nov 2026 | 11 | $1.2M | 32% | +$628K |
| 16 Oct 2026 | 12 | $807K | 92% | -$318K |
| 21 Jan 2028 | 2 | $775K | 95% | -$697K |
| 15 Jan 2027 | 5 | $732K | 4% | -$622K |
| 18 Dec 2026 | 5 | $328K | 40% | +$182K |
| 19 Jan 2029 | 1 | $225K | 100% | +$225K |
The most premium, $1.2M, is aimed at the 20 Nov 2026 expiry; the nearest expiry with unusual prints is 16 Oct 2026.
A print in a contract expiring this week is a view about the next few days, often about a known event; a print months out is a different kind of statement. Read the guide: 0DTE options flow.
The last session, 28 September 2026
| Date | Contract | Type | Size | Open int. | Premium | Execution | Sentiment | Tier |
|---|---|---|---|---|---|---|---|---|
| 28 Sep 2026 | PFE 20 Nov 2026 $27 calls | Sweep | 300 | 14,012 | $63K | At ask | Bullish | Notable |
| 28 Sep 2026 | PFE 18 Dec 2026 $26 calls | Sweep | 100 | 5,068 | $30K | At ask | Bullish | Notable |
Every print in PFE with its full detail, the live tape, one tap filters and saved screeners: open PFE in Options Sentiment Screener.
Price
The live quote and the price chart sit beside the ticker's flow in the app: open PFE in Options Sentiment Screener.
Analysts
The most recent analyst targets on file, from 11 firms, have a median of $28, 2.3% below the last close. The last 90 days brought 1 downgrade.
Calls bought at a strike above the average target are a bet that the analysts are too cautious; puts far below the price in a name they like are protection or a strong disagreement. Read the guide: Reading one ticker's flow.
About Pfizer Inc.
- Exchange
- NYSE
- Sector
- Health Care
- Industry
- Pharmaceutical Products
- Headquarters
- New York, New York
- Website
- pfizer.com
Pfizer Inc. discovers, develops, manufactures, markets, distributes, and sells biopharmaceutical products. It offers medicines and vaccines in various therapeutic areas, including cardiovascular metabolic and women's health. The company also provides biosimilars for chronic immune and inflammatory diseases under the Xeljanz, Enbrel, Inflectra, and Cibinqo brands.
In the same sector
Flow pages for other Health Care names in the S&P 500:
LLY Eli Lilly & Co.JNJ Johnson & JohnsonABBV AbbVie Inc.MRK Merck & Co. Inc.UNH UnitedHealth Group Inc.TMO Thermo Fisher Scientific Inc.AMGN Amgen Inc.GILD Gilead Sciences, Inc.
Learn
- What unusual options activity means
- Reading one ticker's flow
- Sweeps, blocks and where a trade printed
- Size versus open interest
- Bullish or bearish, how a print's sentiment is inferred
- The conviction score and whale prints
The live tape for PFE with every print's execution detail, one tap filters for calls, puts, sweeps and 0DTE, saved screeners and, for Realtime subscribers, push alerts and no delay. The same screen is in the iOS and Android apps.
Open PFE in Options Sentiment Screener